Correlation between Powder Rheology Data and Processability in Solid Dosage Form Manufacturing

from powder characterisation and how the data correlates to process performance and drug product quality in solid dosage form develop ment projects. Data from two development studies will be shown. The development and manufacturing of solid dosage forms relies heavily on powder material. API and tablet excipients are most often handled as a granular material. The powders are mixed and compressed to form a tablet. It is essential to characterise the mixing, flow and compression properties of the powders in order to be able to produce a high quality drug product. Traditional powder characterisation relies on static methods e.g. angle of repose, density and tapped density, but new techniques are emerging in the pharmaceutical R&D laboratory, for example, quasiand dynamic techniques like